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- Vitamin B12 itself was discovered during the investigation of pernicious anemia, a disease condition that destroys epithelial cells in the stomach that secrete intrinsic factor. This intrinsic factor is necessary for vitamin B12 absorption. If vitamin B12 levels are slightly lower than normal, it shows symptoms like fatigue, depression and poor memory. It can also cause symptoms of mania (irritable mood) and psychosis. Vitamin B12 deficiency occurs frequently among elder people, caused primarily by "food-cobalamin malabsorption" (inability to release vitamin B12 from food or its binding proteins) and "pernicious anemia".